Abstract
Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Division / drug effects
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Cell Line, Tumor
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Esters / chemical synthesis
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Esters / pharmacology
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Humans
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Inhibitory Concentration 50
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Pyridines / chemical synthesis*
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Pyridines / pharmacology
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Structure-Activity Relationship
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Telomerase / antagonists & inhibitors*
Substances
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Enzyme Inhibitors
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Esters
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Pyridines
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Telomerase